Health and Fitness

Chlorogenic Acid: Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

The intracellular glucose level and lipid metabolic homeostasis are essential for maintaining vital life-sustaining functions of a cell or organism. The metabolic disorder of lipids and glucose is inextricably linked to the development and progress of obesity, diabetes, hepatic and cancer, and cardiovascular disease. Chlorogenic acid (CGA) is among the most abundant polyphenols in humans, comprises a class of secondary metabolites derived from phenols produced by certain species of plants, and is an essential component in coffee. Evidence has shown that CGA has various biological properties, such as antioxidant, antibacterial and anticarcinogenic properties. Recently, the role and functions of CGA specifically in connection with sugar metabolism and lipid metabolism have been recognized.


The intracellular glucose level and lipid metabolic homeostasis are vital to maintaining the essential life processes of a cell or an organism. Therefore, cellular cytology is a crucial aspect. The intracellular presence of glucose and lipid metabolism issues are the cause of a myriad of metabolic disorders. Diabetes and lipid metabolic conditions are inextricably linked to the development and spread of obesity. And diabetes, heart disease, hepatic-related steatosis, and cancer.  Chlorogenic acid (CGA) is among the most abundant polyphenol compounds found in humans, makes up a class of secondary metabolites containing phenols made by specific plant species, and is a critical component in coffee. Buy chemicals online is not a big issue now a day but it may be dangerous. It was discovered that coffee has the highest levels of polyphenols of all beverages that were analyzed. 

The most commonly used version of CGA is called 5-caffeoylquinic acid (5-CQA). Evidence has shown that CGA is a biological compound with a wide range of properties, such as antioxidant, antibacterial, and anticarcinogenic properties, focusing on hypolipidemic and hypoglycemic effects. CGA has recently been proven to alter lipid and glucose metabolism in vivo in healthy individuals and genetically-related metabolic disorders.

Impacts in Glucose Metabolism


  • The Hypoglycemic as well as the Antidiabetic Effect

Coffee consumption is associated with a lower risk of developing Type two diabetes (T2DM). Which has been proven across all sexes and geographic locations and weight-loss levels. In addition, CGA is a major bioactive component found in coffee, which may offer health benefits. For instance, it was said that daily consumption of 3-4 cups of decaffeinated coffee with large amounts of CGA significantly decreased the risk of developing T2DM by 30%. Chlorogenic acid (CGA) is an innovative insulin sensitizer that enhances insulin activity similar to the therapeutic effect of metformin. Chlorogenic acid (CGA) in 5 mg/kg body weight has antidiabetic properties within streptozotocin (STZ) (45 mg/kg b.w.) rats that are diabetic induced by nicotinamide.

Bassoli et al. (2008) studied the effect of CGA on the hepatic output of glucose and blood glucose levels and tolerance to glucose. The results showed that CGA was able to induce significant reductions in the peak of plasma glucose during the test for oral glucose tolerance. Which is likely due to its ability to reduce intestinal glucose absorption. That suggests the possibility of CGA as an agent that lowers the glycaemic index and also pointing out the potential of this compound. To be that could be beneficial in decreasing the chance to develop T2DM.

CGA has antidiabetic effects by stimulating glucose uptake in insulin-sensitive as well as insulin-resistant Adipocytes. The potency of CGA to produce 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose(2-NBDG) uptake was comparable to the antidiabetic drug rosiglitazone. Furthermore, CGA, unlike thiazolidinedione (TZD) or insulin, cannot cause the development of obesity or any other side consequences.


A variety of studies and research on the impact of CGA on the metabolism of lipids and glucose are being carried out. Although progress has been made, the mechanism behind the metabolism of lipids and glucose is not yet fully understood. In addition, the adverse consequences of CGA haven’t been examined in depth. More research is needed to determine the long-term and short-term impacts of CGA on lipid and glucose metabolism. It is expected that studies on the mechanism of actions of CGA on metabolic processes involving lipids and glucose.  It will be conducted shortly, and information about the potential clinical uses of CGA will grow.

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